Hydroxyurea

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Hydroxyurea Induced Perimalleolar Ulcers

Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Common dermatological side effects include hyperpigmentation, scaling, erythema, alopecia, desquamation of face and hands. Leg ulceration following HU therapy is less common and very few cases have been reported so far. Objective of this paper is to increase the awareness of hydroxyurea induc...

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Hydroxyurea enhances sickle survival.

In this issue of Blood, Voskaridou et al provide more compelling evidence that hydroxyurea improves survival in adults with severe sickle cell disease.1 This comes at the centennial of the recognition of sickle cell disease in Western medicine. Considerable progress has been made in understanding the pathophysiology of this complex disease caused by a single nucleotide change in the -globin gen...

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Hydroxyurea Analogues of Fosmidomycin

Z. Naturforsch. 58b, 106 – 110 (2003); received September 18, 2002 Benzyloxyureas (4) have been prepared by reactions of diethyl 3-benzyloxyamino-propyl-phosphonate (3) with isocyanates, potassium cyanate or 1,1’-carbonyldiimidazole / methylamine. Conversion of phosphonic esters 4 into phosphonic acids 6 by means of bromotrimethylsilane and catalytic hydrogenation of 4, 6 afforded the target co...

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Photodermatosis secondary to hydroxyurea.

To cite: Yanamandra U, Sahu KK, Malhotra P, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-205974 DESCRIPTION A middle aged Southeast-Asian man, recently diagnosed with chronic myeloid leukaemia (Philadelphia positive on FISH), was started on cytoreductive therapy with hydroxyurea due to high leucocyte count (130 000/mL). The patient had no history o...

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Hydroxyurea Induced Longitudinal Melanonychia: A Picture Presentation

This is a picture presentation of myeloproliferative disorder developing to longitudinal melanonychia as a side effect of hydroxyurea. Keywords: Melanonychia, hydroxyurea, side effect.

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1967

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)96181-8